Association of Tumor-Infiltrating Lymphocyte Subtypes with Clinical Characteristics and Prognosis in Young Women with Hormone Receptor–Positive Breast Cancer

作者：Megan E. Tesch, Yue Zheng, Yaileen D. Guzmán‐Arocho, Laura C. Collins, Yujing J. Heng, Nabihah Tayob, Shoshana M. Rosenberg, Kathryn J. Ruddy, Rulla M. Tamimi, Lidia Schapira, Jeffrey Peppercorn, Virginia F. Borges, Steven E. Come, Craig Snow, Eric P. Winer, Elizabeth A. Mittendorf, Ann H. Partridge · 发表于：Clinical Cancer Research · 年份：2025 · DOI：10.1158/1078-0432.ccr-25-0948 · 被引用次数：2 · 研究领域：Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses、Breast Cancer Treatment Studies

PURPOSE: The role of tumor-infiltrating lymphocytes (TIL) remains unclear in hormone receptor (HR)-positive/HER2-negative breast cancer, particularly in young patients, whose immune microenvironment could be altered by age-related host and tumor differences. EXPERIMENTAL DESIGN: Patients with stage I to III HR-positive/HER2-negative tumors were identified from a prospective cohort study of patients with breast cancer diagnosed at age ≤40 years. Multiplexed immunofluorescence and semiautomated quantitative software measured cytotoxic T, non-CD8 T, T regulatory, exhausted T, and PDL1+ cells in stroma and tumor. Univariate analyses assessed differences in clinicopathologic characteristics by high versus low immune infiltration, divided based on median. TIL subtypes were evaluated as a continuous variable per 10% increase in Cox regression analyses for invasive breast cancer-free survival, distant disease-free survival (DDFS), and overall survival, adjusted for clinicopathologic parameters. RESULTS: Among 390 patients, high immune infiltration was associated with increasing age, Black race, grade 3 tumors, and metaplastic or micropapillary histologic subtypes. Over a median follow-up of 8 years, higher stromal and intratumoral non-CD8 T-cell infiltration, T regulatory-cell infiltration, and PDL1 expression were associated with improved invasive breast cancer-free survival. Higher intratumoral non-CD8 T-cell infiltration, T regulatory-cell infiltration, and PDL1 expression were as...