Synthesis of Selenylated Pyridones via Bromide‐Catalyzed Direct C( sp 2 )─H Bond Selenylation of Pyridones With Diselenides

作者：Jinhui Cai, Wenting Zhang, Zijing Xing, Wei Zhang, Depeng Yang, Yutao Peng, Zi Yang, Mingming Yu, Feng Zhao · 发表于：Chemistry - An Asian Journal · 年份：2025 · DOI：10.1002/asia.70391 · 被引用次数：6 · 研究领域：Organoselenium and organotellurium chemistry、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

A straightforward and sustainable platform for the efficient assembly of selenylated pyridones with pyridones and diselenides enabled by a cheap and green bromide catalyst was successfully reported. This method was highlighted by its readily available starting materials, metal-free, stoichiometric oxidant-free, simple catalytic system, and wide functional group compatibility. The potential synthetic utility of this strategy was demonstrated by its scalable-up reaction and diverse transformations. The preliminary mechanistic experiments revealed that a radical pathway was possibly involved.