Association between anxiety disorders and medication adherence in patients with cardiovascular disease: a systematic review and meta-analysis of observational studies

作者：Tingting Wang, Zhiyong Li, Yunjie Wei, Xiaofei Zhang, Xiaofei Zhang, Qianjiao Yuan, Xiaohong Zhang, Xiaohong Zhang, Xuying Li, Quan Lei · 发表于：BMC Psychiatry · 年份：2025 · DOI：10.1186/s12888-025-07350-w · 被引用次数：6 · 研究领域：Medication Adherence and Compliance、Attention Deficit Hyperactivity Disorder、Perfectionism, Procrastination, Anxiety Studies

BACKGROUND: The management of cardiovascular (CV) diseases is considerably hindered by the presence of anxiety disorders, which act as a significant barrier to medication adherence. This systematic review and meta-analysis aim to synthesize existing evidence on the relationship between anxiety and medication adherence in individuals with CV diseases. METHODS: A systematic search was conducted across five major databases from inception to 2025. The methodological quality of the included studies was assessed using the National Institutes of Health (NIH) quality assessment tool. A random-effects meta-analysis was conducted utilizing Comprehensive Meta-Analysis software (version 3), with with p < 0.05 indicating significance. RESULTS: A total of 23 studies were selected, including 18 with cross-sectional and five with a longitudinal study design. The combined sample size was 72,815 participants, with an average age of 60.7 years and 51.7% were male participants. Majority of studies (n = 15) reported a negative association between anxiety and cardiovascular (CV) medication adherence. Meta-analysis (n = 20) further supported this overall negative association (SMD = -1.087, 95% CI [-1.469, -0.705], p < 0.001) which was also evident across clinical subgroups: hypertension (SMD = -0.648, 95% CI [-1.293, -0.004], p = 0.049), congestive heart failure (SMD = -0.51, 95% CI [-0.92, -0.10], p = 0.02), and ischemic heart disease (SMD = -2.322, 95% CI [-3.498, -1.146], p < 0.001). CONCLUSION:...