The nomenclature of fatty liver disease and its impact on obesity traits, insulin resistance, and hepatic fibrosis

作者：Liangguang Xiang, Xiaoyun Li, Jiamin Gong, Long He, Wanxin Li, Jun Chen, Ruimei Feng, Shanshan Du, Weimin Ye · 发表于：Lipids in Health and Disease · 年份：2025 · DOI：10.1186/s12944-025-02736-x · 被引用次数：3 · 研究领域：Liver Disease Diagnosis and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins、Alcohol Consumption and Health Effects

BACKGROUND: Definitions of nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated FLD (MAFLD), and steatotic liver disease (SLD) have been proposed to better guide clinical practice and epidemiological studies. The effects of the nomenclature on the incidence of FLD and its associations with obesity phenotypes, insulin resistance (IR), and liver fibrosis were examined in this study. METHODS: NAFLD, MAFLD, and metabolic dysfunction-associated steatotic liver disease (MASLD) were diagnosed on the basis of ultrasound examination and metabolic disorders among 6,718 community-dwelling individuals from southeast China. Six obesity phenotypes, seven IR surrogates, and the NAFLD Fibrosis Score (NFS) were applied to evaluate their association with FLDs through multivariable logistic regression models, restricted cubic splines, and receiver operating characteristic curves. RESULTS: The prevalence of FLD, NAFLD, MAFLD, and MASLD was 35.47%, 33.34%, 34.77%, and 32.79%, respectively. The associations of obesity-FLD, IR-FLD, and FLD-NFS were statistically significant across all the FLD definitions. Patients with MAFLD demonstrated slightly higher odds ratios (ORs) than those with FLD, NAFLD, and MASLD. However, alcoholic-FLD (AFLD), which is included in the MAFLD nomenclature, showed lower ORs with obesity and IR and lower NFS, significantly differently from other FLDs. Among all obesity and IR indices, triglyceride and glucose index body mass index (TyG-BMI), the TyG-w...