Dandruff scalp microbiome exhibits flake severity and sex-related differences

作者：Bo Liang, Mingming Pu, Yining Xu, Yingjie Li, Jianing N. Sun, Yuelin Zhu, Chandraprabha Doraiswamy, Tony Dadd, Chung-Ching Chu · 发表于：British Journal of Dermatology · 年份：2025 · DOI：10.1093/bjd/ljaf099 · 被引用次数：3 · 研究领域：Nail Diseases and Treatments、Facial Rejuvenation and Surgery Techniques、Veterinary Equine Medical Research

BACKGROUND: Dandruff is a prevalent scalp condition characterized by flakiness and itchiness. Its severity can be assessed clinically based on the grade of flakes and coverage area of flakes adhering to the scalp. Dysbiosis of the scalp microbiome is a key factor associated with dandruff, as revealed by studies comparing healthy individuals with those with dandruff. OBJECTIVES: This study further investigated the interplay between microbiome alterations and dandruff severity, and whether these changes are consistent across different sexes. METHODS: Dandruff condition was assessed using the Total Weighted Head Score for Adherent Flakes (TWHS AF). Male and female participants with lower dandruff severity (TWHS AF = 32-40 inclusive) and higher dandruff severity (TWHS AF ≥ 44) were recruited following ethical clearance of the study and obtaining informed consent. Scalp bacterial composition was investigated by 16S rRNA amplicon sequencing. The absolute abundance of key scalp microbes was quantified by quantitative polymerase chain reaction. RESULTS: Notable microbiome compositional differences were observed between scalps with lower and higher dandruff severity. More severe dandruff exhibited a significantly reduced abundance of Cutibacterium acnes and elevated levels of Staphylococcus capitis and Corynebacterium spp. The absolute numbers of Malassezia restricta significantly increased with increased dandruff severity, while M. globosa remained similar. Additionally, distinctive ...