Fabrication and characterization of polysaccharide-based microspheres for ciprofloxacin delivery with controlled release and antimicrobial activity

作者：Qurat ul Ain Ameer, Shazia Akram Ghumman, Huma Hameed, Sobia Noreen, Shazia Noureen, Rizwana Kausar, Ali Irfan, Katarzyna Kotwica-Mojzych, Fozia Batool, Mariola Głowacka, M. S. Raña, Mariusz Mojzych, Yousef A. Bin Jardan · 发表于：RSC Advances · 年份：2025 · DOI：10.1039/d5ra06745f · 被引用次数：5 · 研究领域：Advanced Drug Delivery Systems、Drug Solubulity and Delivery Systems、Hydrogels: synthesis, properties, applications

release studies confirmed the successful incorporation of CIP into the microspheres without compromising their functional properties. The Korsmeyer-Peppas model was the best fit for drug release data, indicating that ciprofloxacin release followed a non-Fickian (anomalous) diffusion pattern, representing a synergistic contribution of both diffusion and polymer chain relaxation mechanisms. The microspheres exhibited promising potential for drug delivery, while antibacterial assays demonstrated a significant inhibitory effect, attributed to the sustained release of ciprofloxacin. This study highlights the potential of alginate and cress seed-based microspheres as efficient carriers for the controlled release of ciprofloxacin.