Accurate myocardial T1 mapping at 5T using an improved modified Look-Locker inversion recovery method: A validation study

作者：Linqi Ge, Yinuo Zhao, Yubo Guo, Yuanyuan Liu, Yihang Zhou, Haifeng Wang, Dong Liang, Hairong Zheng, Yining Wang, Yanjie Zhu · 发表于：Journal of Cardiovascular Magnetic Resonance · 年份：2025 · DOI：10.1016/j.jocmr.2025.101974 · 被引用次数：2 · 研究领域：Cardiac Imaging and Diagnostics、Advanced MRI Techniques and Applications、Cardiovascular Function and Risk Factors

BACKGROUND: Accurate myocardial T1 mapping at 5T remains a technical challenge due to field inhomogeneity and prolonged T1 values. The aim of this study was to develop an accurate and clinically applicable myocardial T1 mapping technique for 5T magnetic resonance imaging systems and validate its performance in a multicenter study. METHODS: variations over the heart at 5T, using adiabatic hyperbolic secant and tangent/hyperbolic tangent (Tan/Tanh) pulses. The method was validated in phantom experiments, as well as in 21 healthy volunteers and 9 patients. RESULTS: = 8 ms. In phantom studies, coMOLLI showed high accuracy versus reference inversion recovery-fast spin echo, yielding relative errors within 5% for all nine vials. In in vivo studies, the average native myocardial T1 values across 21 healthy volunteers were 1468 ± 48 ms, 1514 ± 39 ms, and 1545 ± 50 ms, and blood T1 values were 2182 ± 132 ms, 2124 ± 153 ms, and 2131 ± 158 ms for apical, middle, and base slices, respectively. CONCLUSION: The coMOLLI method demonstrated high accuracy in phantom studies and feasibility in vivo studies. By adopting the widely used 5-(3)-3 MOLLI acquisition scheme, it shows potential for clinical cardiac imaging at 5T.