Endogenous Electric Fields: A Natural Driver for Infrared-Activated Transparent Electronic Skin in Wound Healing

作者：Futing Wang, Su-Ping Deng, Linxuan Liu, Ningbo Zhang, Changxiao Song, Yutang Zhou, Xiaofei Fu, Yuting Jiang, Man Liu, Yueqiang Hu, Hongfen Yang, Dan Yang, Wenbin Zhong, Zhuo Chen, Ren Cai, Weihong Tan · 发表于：Nano Letters · 年份：2025 · DOI：10.1021/acs.nanolett.5c04223 · 被引用次数：10 · 研究领域：Planarian Biology and Electrostimulation、Advanced Sensor and Energy Harvesting Materials、Neuroscience and Neural Engineering

A flexible, self-powered, and transparent electronic skin (e-skin) is constructed by combining endogenous electric field modulation and infrared thermal stimulation to accelerate wound healing. The e-skin comprises (1) a transparent conductive layer for real-time wound monitoring, fabricated by thermal deposition of hexadecyltrimethylammonium bromide (CTAB)-functionalized carbon nanotubes (C-MWCNTs) with polydimethylsiloxane (PDMS); (2) a photothermal interface using Pd@Au nanoframes for infrared therapy; and (3) self-powered electric fields mimicking bioelectric signals. Antibacterial assays of the e-skin showed >160% bacterial suppression at the peak output of 0.25–0.59 V and 90–140% suppression at the baseline output of 0.05–0.12 V. In vitro tests demonstrated 90% E. coli elimination within 10 min. In vivo studies on rabbits revealed a 50% reduction in healing time (7 days) via synergistic photothermal-electrical therapy. This e-skin offers a promising approach to advanced wound care.