Boron Neutron Capture Therapy as a Novel Approach for Chondrosarcoma: Case Study of Tumor Reduction and Long-term Control

作者：Junqiang Hong, Yuan‐Hao Liu, Xiaohua Zhu, Yi-Chiao Teng, Xiaoyi Lin, Diyun Shu, Youqun Lai, Ye Cao, Qiuping Gong, Shuang Fu, Wenyu Xu, Qiuli Lai, Xingyan Liu, Ping Zhou, Mu Mei, Mingang Ying, Cheng Huang, Jianji Pan · 发表于：Advances in Radiation Oncology · 年份：2025 · DOI：10.1016/j.adro.2025.101897 · 被引用次数：6 · 研究领域：Boron Compounds in Chemistry、Bone health and treatments、Boron and Carbon Nanomaterials Research

Purpose Mesenchymal chondrosarcoma (MCS), a rare malignant tumor arising from cartilage-forming tissues, is known for its resistance to conventional therapies. This case report presents the first documented use of boron neutron capture therapy (BNCT) for treating a patient with chondrosarcoma. Methods and Materials The treatment was carried out using the NeuPex AB-BNCT system in combination with the boron compound NBB-001 (boronophenylalanine) and the NeuMANTA treatment planning system. Over the course of 2 BNCT sessions, the patient experienced significant tumor reduction and a favorable clinical response, with no severe adverse effects reported. The therapy was guided by 18 F-boronophenylalanine positron emission tomography-computed tomography imaging scans for planning and magnetic resonance imaging scans for outcome assessment. Results The targeted nature of BNCT resulted in a 45.8% reduction in the tumor's maximum dimension, achieving a partial response according to Response Evaluation Criteria in Solid Tumors version 1.1. Most adverse events were mild (grades 1-2) and manageable, with only grade 3 mucositis observed, which was transient and resolved with supportive care. Conclusions This case study underscored the potential of BNCT as a promising treatment modality for MCS, particularly for tumors that are resistant to conventional radiation therapy. Further research is warranted to refine treatment protocols and explore the broader applicability of BNCT in managing MCS...