Neuroimaging evidence for central mechanisms of acupuncture in non-specific low back pain: a systematic review and meta-analysis

作者：Frank Fan Huang, Jiajun Liu, Ming Lü, Yunshan Wu, Shanshan Zhen, Yihui Cai, Zhaoxue Liu, Zhaoxue Liu, Mingwang Qiu, Wenwu Xiao, Yu‐Xi Huang, Junquan Liang, Min Li, Zaigao Liu, Zaigao Liu · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1657241 · 被引用次数：3 · 研究领域：Acupuncture Treatment Research Studies、Musculoskeletal pain and rehabilitation、Pain Mechanisms and Treatments

Objectives: Non-specific low back pain (NSLBP) is a prevalent disorder with significant global health impacts. This systematic review and meta-analysis assessed acupuncture's clinical effectiveness for NSLBP and explored its brain mechanisms using fMRI. Methods: A comprehensive search of multiple databases (PubMed, Embase, Cochrane Library, Web of Science, Science Direct, China National Knowledge Infrastructure, Wanfang Data, Chinese Technical Periodicals Database, and Chinese Biomedical Literature Database) was conducted from inception to July 11th, 2024. We included randomized controlled trials (RCTs) or non-RCTs resting-state functional magnetic resonance imaging to observe the effect of acupuncture on NSLBP. GingerALE 3.0.2 was used as the meta-analysis tool, and meta-analysis was performed in the Montreal Neurological Institute coordinate space. Results: < 0.001). Neuroimaging analyses revealed distinct brain activation patterns: acute NSLBP showed positive activation in the right sub-lobar insula, inferior parietal lobule, medial frontal gyrus, and cingulate gyrus, while chronic NSLBP demonstrated positive activation in bilateral sub-lobar insula and negative activation in motor and prefrontal regions. Conclusion: Acupuncture shows significant efficacy for NSLBP, modulating pain processing through the insula and limbic system. While these results suggest therapeutic potential for both acute and chronic NSLBP, higher-quality research is needed to validate these mechanism...