Carotid and regional arterial stiffness and dementia‐related imaging biomarkers in the Multi‐Ethnic Study of Atherosclerosis (MESA)

作者：Sheina Emrani, Jordan E. Tanley, Christopher L. Schaich, Sanjiv J. Shah, Alain G. Bertoni, Claudia E. Korcarz, Susan R. Heckbert, Mohamad Habes, Samuel N. Lockhart, Julio A. Chirinos, Jingzhong Ding, James H. Stein, Adam D. Gepner, R. Nick Bryan, Ilya M. Nasrallah, José A. Luchsinger, Kathleen M. Hayden, Yongmei Liu, Timothy M. Hughes · 发表于：Alzheimer s & Dementia · 年份：2025 · DOI：10.1002/alz.70688 · 被引用次数：3 · 研究领域：Cardiovascular Health and Disease Prevention、Cerebrovascular and Carotid Artery Diseases、Dementia and Cognitive Impairment Research

INTRODUCTION: Arterial stiffness measured within various arterial beds may be differentially associated with neuroimaging biomarkers of dementia. METHODS: We related carotid and regional (cardio-ankle vascular index [CAVI] and heart-ankle pulse wave velocity [haPWV]) arterial stiffness measures to biomarkers (gray matter volume [GMV], white matter hyperintensity volume [WMHV], and fractional anisotropy [WMFA]) and amyloid positron emission tomography (PET) positivity (centiloid > 12.2), controlling for covariates. RESULTS: All arterial stiffness measures were associated with higher WMHV. Lower carotid distensibility (increased mechanical stress) was positively associated with WMFA, while Young's elastic modulus and haPWV (greater stiffness) were associated with lower WMFA. Only CAVI was significantly related to amyloid PET positivity, although similar effect sizes were observed for carotid measures. No main associations were observed with GMV. Significant interactions showed men and Black and Hispanic participants had stronger associations between carotid stiffness and GMV. CONCLUSIONS: Carotid stiffness measures were associated with WM injury while regional CAVI measures were associated with amyloid positivity. HIGHLIGHTS: We studied differences between carotid ultrasound and regional (cardio-ankle vascular index [CAVI] and heart-ankle pulse wave velocity [haPWV]) measures of arterial stiffness and neuroimaging abnormalities (white matter changes and amyloid positron emissio...