Multimodal Imaging-Based Cerebral Blood Flow Prediction Model Development in Simulated Microgravity

作者：Linkun Cai, Yawen Liu, Kai Li, Changyang Xing, Zi Xu, Lianbi Zhao, Ke Lv, Zhili Li, Hao Wang, Linjie Wang, Dehong Luo, Lijun Yuan, Lina Qu, Yinghui Li, Zhenchang Wang, Pengling Ren · 发表于：Cyborg and Bionic Systems · 年份：2025 · DOI：10.34133/cbsystems.0448 · 被引用次数：6 · 研究领域：Spaceflight effects on biology

Background: Abnormal alterations in cerebral blood flow (CBF) have been implicated in cognitive decline and neurodegeneration. Maintaining adequate CBF in astronauts during long-duration microgravity is therefore crucial for the success of manned spaceflight. However, the quantitative assessment of CBF during space missions remains challenging. Methods: Thirty-six participants underwent a 90-d −6° head-down tilt bed rest (HDTBR) protocol, a well-established ground-based analog of microgravity. Multimodal imaging data, including internal carotid artery Doppler ultrasound and brain magnetic resonance imaging, were collected during HDTBR. Multiple machine learning (ML) algorithms were developed to investigate carotid–CBF mapping relationship and establish CBF change prediction models. Results: After 90-d HDTBR, significant regional CBF decreases were observed, primarily in the right Heschl’s gyrus, right middle cingulate gyrus, and right superior frontal gyrus. The optimal ML model CatBoost showed robust predictive performance for CBF in these regions (right Heschl’s gyrus: AUC = 0.88, accuracy = 0.84; right middle cingulate gyrus: AUC = 0.92, accuracy = 0.83; right superior frontal gyrus: AUC = 0.82, accuracy = 0.72). To enhance accessibility and practical utility, the prediction model was implemented as an interactive web application for in-orbit deployment. Conclusion: This study demonstrates the feasibility of constructing ML-driven CBF prediction models under microgravity b...