Age-Specific Cardiovascular and Platelet Dynamics in Kawasaki Disease

作者：Fen Wang, Zhixi Lu, Haitao Lv · 发表于：International Journal of General Medicine · 年份：2025 · DOI：10.2147/ijgm.s515118 · 被引用次数：1 · 研究领域：Kawasaki Disease and Coronary Complications、Coronary Artery Anomalies、Cardiovascular Issues in Pregnancy

Objective: To characterise age-specific differences in clinical manifestations, treatment response and platelet dynamics in Kawasaki disease (KD). Methods: A retrospective analysis was conducted on 221 patients with KD who were admitted to the cardiology department of Suzhou Children’s Hospital between June 2015 and May 2016. Patients were divided into three groups based on age: the infant group (≤ 12 months), the toddler group (> 12 months to ≤ 36 months) and the child group (> 36 months to ≤ 10 years). Clinical symptoms, signs, echocardiography (ECHO) findings, treatment characteristics and platelet counts were compared among the groups. Multivariate logistic regression was performed to identify independent predictors of severe cardiovascular damage. A P -value of < 0.05 was considered significant. Results: Major symptoms, such as lymph node enlargement and finger (toe) peeling, were significantly more pronounced in the toddler and child groups ( P < 0.05). The overall incidence of cardiovascular damage was 56.1%, with 31.7% experiencing intravenous immunoglobulin (IVIG) resistance. Treatment delay (≥ 10 days from fever onset) occurred in 18.6% of cases and was associated with increased cardiovascular severity (adjusted odds ratio [aOR] = 2.45, 95% confidence interval [CI] 1.32– 4.56, P = 0.004). Platelet counts and plateletcrit increased significantly during the acute and subacute phases, with the infant group exhibiting significantly higher platelet responses than the tod...