Cu single-atom embedded g-C3N4 nanosheets rehabilitate multidrug-resistant bacteria infected diabetic wounds via photoswitchable cascade reaction

作者：Xichen Sun, Pengqi Zhu, Liuyan Tang, Pengfei Wang, Ningning Li, Qing Wang, Yan‐Ru Lou, Yuezhou Zhang, Peng Li · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-64242-z · 被引用次数：45 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced Photocatalysis Techniques

Abstract To tackle elevated blood glucose, multidrug-resistant (MDR) bacterial infections, and persistent inflammation in diabetic wounds, we present a therapeutic strategy that employs a photoswitch-controlled catalytic cascade reaction, utilizing a photocatalytic material engineered through the synergistic regulation of nitrogen vacancies and single-atom embedding. Under visible light illumination, the N vacancy exist in g-C 3 N 4 (CN) significantly enhances photocatalytic glucose oxidation to regulate the hyperglycemia condition at diabetic wound sites, and the atomically dispersed Cu promotes the generation of •OH and •O 2 – to efficiently eliminate MDR bacteria ( > 99.9%). Under dark conditions, excess ROS are scavenged by Cu/CN, reducing inflammation of wounds and promoting polarization of M2 macrophages. Serum biochemical and vital organs histopathological analyses after 14 days of treatment confirm the biosafety profile of Cu/CN. This photoswitchable cascade reaction effectively treats MDR bacterial-infected diabetic wounds in male mice, highlighting its potential for antibiotic-free therapy with promising clinical translation applications.