Serum phthalates and risks of incident cardiovascular disease among individuals with type 2 diabetes in a prospective cohort study

作者：Shiyang Zhang, Cheng Xu, Chengyong Jia, Jun An, Xin Zhang, Youbing Guan, Yan Yan, Zhuoya Zhao, Yuenan Liu, Tao Jing, Meian He · 发表于：Eco-Environment & Health · 年份：2025 · DOI：10.1016/j.eehl.2025.100185 · 被引用次数：4 · 研究领域：Effects and risks of endocrine disrupting chemicals

= 0.03, 0.02, and 0.02, respectively] after multiple adjustment in Cox proportional hazard models. Meanwhile, linear associations for serum di-iso-butyl phthalate (DiBP), DnBP, ΣDBP, and ΣLMW, and a nonlinear U-shaped dose-response association for serum butyl-benzyl phthalate (BBP) with incident stroke risk were proved by restricted cubic spline regression analyses. Furthermore, a positive correlation between PAE mixture and incident stroke risk was identified in Quantile-based g-computation [HR (95%CI): 1.24 (1.05, 1.46)]. However, serum PAEs, either as individuals or as a mixture, were not associated with incident CVD or coronary heart disease risk. Our study revealed that serum PAEs were positively associated with increased incident stroke risk in the T2DM population. More prospective cohort and mechanism studies are warranted to validate our findings.