IL-5, IL-31 and systemic immune-inflammation index as biomarkers predicting severity and progression in bullous pemphigoid

作者：Yanyu Zhang, Xia Liu, Lili Hou, Yan Zhao, Jiaxuan Hao, Na Zhang, Jing Tian, Xiaoqing Li, Zhiyu Liu, Hongwei Zhou, Hongwei Zhou, Chunyang Xu, Yuan Ren, Haizhou Zhou, Haizhou Zhou · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1657952 · 被引用次数：1 · 研究领域：Autoimmune Bullous Skin Diseases、Dermatology and Skin Diseases、Psoriasis: Treatment and Pathogenesis

Introduction Inflammatory mechanisms assume a pivotal role in bullous pemphigoid (BP). IL-31, IL-5, and the systemic immunoinflammatory index (SII) are emerging markers of inflammatory activity, but their associations with BP severity remain unclear. This investigation sought to investigate the correlation of the three aforementioned indicators with BP disease severity to determine their potential application in predicting BP severity. Methods This study enrolled 83 BP patients and 50 healthy controls (HC). Patients were stratified into mild-moderate (MM, n = 23) and severe (Sev., n = 60) groups based on body surface area (BSA) involvement. Serum IL-5 and IL-31 levels were measured by Chemiluminescence Immunoassay (CLIA) and ELISA. The SII was calculated as platelets × neutrophils/lymphocytes. Differences between groups were assessed using non-parametric tests, correlations were analyzed using Spearman’s correlation, and predictive performance was evaluated using logistic regression and ROC curves. Five patients underwent longitudinal IL-31 and IL-5 measurement pre- and post-treatment. Results Interleukin-31 and IL-5 levels were significantly raised in BP versus HC (median [Q1–Q3]: IL-5: 2.86 [1.22–7.10] vs. 0.79 [0.65–1.00] pg/mL; IL-31: 103.61 [77.42–146.77] vs. 86.02 [51.49–122.53] pg/mL), with further increases in Sev. versus MM groups (IL-5: 3.84 [1.57–10.63] vs. 1.35 [0.83–2.93] pg/mL; IL-31: 125.99 [91.58–173.85] vs. 65.14 [51.27–85.47] pg/mL). Post-treatment IL-31 dec...