Recent Advances in Secondary Metabolites from Marine Aspergillus

作者：Zimin Wang, Meirong Zhao, Chenglin Li, Chenglin Li, Yunxia Yu, Zhiqiang Gong, Fandong Kong, Chengzhi Li, Chengzhi Li · 发表于：Marine Drugs · 年份：2025 · DOI：10.3390/md23100400 · 被引用次数：5 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Seaweed-derived Bioactive Compounds

Marine Aspergillus fungi, adapted to extreme marine environments (e.g., sediments, corals, mangroves), are prolific producers of structurally diverse secondary metabolites with significant bioactivities. This review comprehensively analyzes 340 novel natural products reported from 81 marine-derived Aspergillus strains over the past three years, classifying them into six major categories: alkaloids (31.2%), polyketides (29.4%), terpenoids, lignans, cyclopeptides, and others. Bioactivity assessments reveal broad therapeutic potential, including antitumor, antimicrobial, anti-inflammatory, and antiviral effects. Notably, marine sediments constitute the primary source (25.9% of strains), followed by sponges and corals. The predominance of alkaloids and polyketides underscores their pharmacological relevance. These findings highlight marine Aspergillus as a critical resource for drug discovery, offering promising scaffolds for developing treatments against human diseases and agricultural pathogens.