MIMOSA : Multi‐Parametric Imaging Using Multiple‐Echoes With Optimized Simultaneous Acquisition for Highly‐Efficient Quantitative MRI

作者：Yuting Chen, Yohan Jun, Amir Heydari, Xingwang Yong, Jiye Kim, Jongho Lee, Huafeng Liu, Huihui Ye, Borjan Gagoski, Shohei Fujita, Berkin Bilgiç · 发表于：Magnetic Resonance in Medicine · 年份：2025 · DOI：10.1002/mrm.70143 · 被引用次数：4 · 研究领域：Advanced MRI Techniques and Applications、Advanced NMR Techniques and Applications、Electron Spin Resonance Studies

ABSTRACT Purpose To develop a new sequence, MIMOSA, for highly efficient T 1 , T 2 , T 2 *, proton density (PD), and source separation quantitative susceptibility mapping (QSM). Methods MIMOSA was developed based on 3D quantification using an interleaved Look‐Locker acquisition sequence with a T 2 preparation pulse (3D‐QALAS) by combining 3D turbo Fast Low Angle Shot (FLASH) and multi‐echo gradient echo acquisition modules with a spiral‐like Cartesian trajectory to facilitate highly efficient acquisition. Simulations were performed to optimize the sequence. A multi‐contrast/‐slice zero‐shot self‐supervised learning algorithm was employed for reconstruction. The accuracy of quantitative mapping was assessed by comparing MIMOSA with 3D‐QALAS and reference techniques in both ISMRM/NIST phantom and in vivo experiments. MIMOSA's acceleration capability was assessed at R = 3.3, 6.5, and 11.8 in in vivo experiments, with repeatability assessed through scan‐rescan studies. Beyond the 3 T experiments, mesoscale quantitative mapping was performed at 750 μm isotropic resolution at 7 T. Results Simulations demonstrated that MIMOSA achieved improved parameter estimation accuracy compared to 3D‐QALAS. Phantom experiments indicated that MIMOSA exhibited better agreement with the reference techniques than 3D‐QALAS. In vivo experiments demonstrated that an acceleration factor of up to R = 11.8‐fold can be achieved while preserving parameter estimation accuracy, with intra‐class correlation co...