Analysis of inflammatory response and its factors after dental implant surgery in patients with type 2 diabetes

作者：Zibo Li, Haochen Yu, Liang Hong · 发表于：World Journal of Diabetes · 年份：2025 · DOI：10.4239/wjd.v16.i10.110140 · 被引用次数：3 · 研究领域：Dental Implant Techniques and Outcomes、Oral microbiology and periodontitis research、Dental Radiography and Imaging

BACKGROUND: Dental implants are widely used to replace missing teeth. Currently, clinicians assess osseointegration success by measuring the implant's stability within the bone and monitoring the marginal tissue height. Diabetes, especially type 2 diabetes mellitus (T2DM), has been reported to impair implant healing, drastically reducing implant success rates. AIM: To analyze the high-risk factors for inflammatory response and prognosis after dental implantation in patients with T2DM, and provide strong evidence for reducing the incidence of postimplant peri-implantitis (PI). METHODS: We performed a retrospective review of 146 patients with T2DM who had dental implants placed at Tianjin Fifth Central Hospital, between September 2021 and September 2023, which was regarded as the observation group. Moreover, 60 age- and gender-matched individuals with normal blood glucose levels served as the control group. The general information, postoperative periodontal indices, and levels of inflammatory factors were comprehensively analyzed and compared. Furthermore, the incidence of postimplant PI was counted, and multivariate logistic regression was used to identify the determinants of postimplant PI. RESULTS: In terms of the periodontal indices, the probing depth, modified sulcus bleeding index, and marginal bone loss in the observation cohorts began to increase significantly at 6 months and 3 months, respectively, after the completion of dental implant restoration. The T2DM cases demo...