Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force

作者：Dimosthenis Tsapekos, Michail Kalfas, Johanna Mariegaard Schandorff, Caterina del Mar Bonnín, Christopher R. Bowie, Vicent Balanzá‐Martínez, Katherine E. Burdick, André F. Carvalho, Annemiek Dols, Katie M. Douglas, Peter Gallagher, Gregor Hasler, Lars Vedel Kessing, Hanne Lie Kjærstad, Beny Lafer, Kathryn E. Lewandowski, Carlos López‐Jaramillo, Anabel Martínez‐Arán, Roger S. McIntyre, Richard Porter, Scot E. Purdon, Ayal Schaffer, Paul Stokes, Tomiki Sumiyoshi, Ivan J. Torres, Tamsyn E. Van Rheenen, Lakshmi N. Yatham, Jeff Zarp Petersen, Allan H. Young, Eduard Vieta, Kamilla Woznica Miskowiak · 发表于：Acta Psychiatrica Scandinavica · 年份：2025 · DOI：10.1111/acps.70038 · 被引用次数：3 · 研究领域：Bipolar Disorder and Treatment、Treatment of Major Depression、Electroconvulsive Therapy Studies

INTRODUCTION: Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro-cognitive interventions show promise, trial findings are inconsistent, potentially due to baseline factors influencing treatment response. This systematic review summarizes evidence on pre-treatment characteristics associated with cognitive improvement and offers methodological recommendations. METHODS: A systematic search was conducted in PubMed/MEDLINE, EMBASE, PsycINFO, and Cochrane Library from inception to February 28, 2025. Eligible studies included primary or secondary analyses of randomized controlled trials (RCTs) investigating predictors of cognitive response to pro-cognitive interventions in MDD and/or BD. Two researchers independently conducted study selection and risk of bias assessments. Findings were synthesized qualitatively. RESULTS: Forty studies (N = 3864) were identified, covering pharmacological treatments (k = 20; N = 2299), psychological therapies (k = 16; N = 1165), brain stimulation (k = 2; N = 168), and physical activity (k = 2; N = 232). Poorer baseline cognitive performance was the most consistent predictor of greater cognitive improvement, though the direction of the effect was not entirely uniform across all studies. Baseline depression severity showed no significant association with cognitive outcomes. Age, education, sex, IQ, diagnosis, and medication status were similarl...