Fusobacterium in the microbiome: from health to disease across the oral–gut axis and beyond

作者：Zhengrui Li, Jian Liu, Jing Li, Zhaokai Zhou, Xufeng Huang, Divya Gopinath, Peng Luo, Qi Wang, Dan Shan · 发表于：npj Biofilms and Microbiomes · 年份：2025 · DOI：10.1038/s41522-025-00838-z · 被引用次数：31 · 研究领域：Otolaryngology and Infectious Diseases、Streptococcal Infections and Treatments、Oral Health Pathology and Treatment

Fusobacterium functions as both commensal and pathogen, linking the oral-gut axis to diverse diseases, including cancer. Evidence shows it modulates microbial balance, promotes dysbiosis, and contributes to carcinogenesis by driving inflammation, proliferation, invasion, and immune evasion. This review integrates ecological, molecular, and clinical insights, highlighting its roles in oral and systemic disease and discussing therapeutic potential, underscoring Fusobacterium's dualistic nature and implications for microbiome-targeted interventions.