Hyperwightianols I-N, six new meroterpenoids from Hypericum wightianum

作者：Chuan-Lu Fu, Ping Ying, Wei-Ming Huang, Ze Liu, Zi-Wei Jia, Qiang Zheng, You-Jun Wu, Lingyi Kong, Wen‐Jun Xu · 发表于：Journal of Asian Natural Products Research · 年份：2025 · DOI：10.1080/10286020.2025.2567445 · 研究领域：Natural Compound Pharmacology Studies、Biological Activity of Diterpenoids and Biflavonoids、Phytochemistry and Biological Activities

Six undescribed meroterpenoids, designated as hyperwightianols I-N (1–6), were isolated from the dried whole herb of Hypericum wightianum. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), 1D & 2D nuclear magnetic resonance spectroscopy (NMR), as well as electronic circular dichroism (ECD). Compounds 1–3 featured a chromone core hybridized with a monoterpene unit (geranyl or geranyl-derived groups), while 4–6 were characterized by benzoic acid or cinnamic acid cores hybridized with a lavandulyl unit. In all cases, the monoterpene fragments were linked to the core structures via C-4 ether bond.