Spermidine reduces peri-implant inflammation and fibrosis to nurture osseointegration

作者：Qiming Liu, Qianqian Wu, Tingting Cao, Rundong Miao, Chenyu Wang, Jiawei Zhang, Xueqin Gao, Li Wang, Guoxin Shi, Jinyu Lai, Runjiao Yang, Xianshu Piao, Jiaao Yu, Jincheng Wang, Song Liang, Shuqing Kou, Thomas M. Roberts, Bingdi Wang, Zhenning Liu · 发表于：Bioactive Materials · 年份：2025 · DOI：10.1016/j.bioactmat.2025.09.036 · 被引用次数：1 · 研究领域：Silk-based biomaterials and applications、RNA Interference and Gene Delivery、Antimicrobial agents and applications

-FBR activity by regulating host response and nurture peri-implant niche to improve osseointegration of metal implants. Hence, spermidine affords a natural and elegant strategy to alleviate FBR against medical implants.