The association between abnormal glucose metabolism and rheumatoid arthritis

作者：Xiaoyu Zhang, Fanyan Meng, Zhidan Wang, Shuang Ren, Jie Zhang · 发表于：Experimental and Molecular Pathology · 年份：2025 · DOI：10.1016/j.yexmp.2025.105001 · 被引用次数：3 · 研究领域：Metabolism, Diabetes, and Cancer、Liver Disease Diagnosis and Treatment、Diabetes and associated disorders

The research has found that the incidence of rheumatoid arthritis (RA) combined with Type 2 Diabetes Mellitus (T2DM) and insulin resistance (IR) is higher than that in the general population. This indicates that there is an association mechanism between RA and abnormal glucose metabolism. IR is one of the main causes of T2DM, and high blood glucose levels are one of the main symptoms of T2DM. Therefore, revealing the intrinsic mechanism between RA and the abnormal glucose metabolism in T2DM becomes the key to treating RA complicated with T2DM. This article summarizes the mechanism of RA combined with T2DM, which is mainly caused by the disorder of glucose metabolism and the persistent presence of inflammatory mediators. The synovial hyperplasia, angiogenesis and bone destruction of RA interact with the abnormal glucose metabolism. Therefore, elaborating the intrinsic connection and interaction mechanism between abnormal glucose metabolism and RA, and summarizing the abnormal glucose metabolism phenomenon of increased prevalence of T2DM in RA patients in clinical practice, can provide a reference for future in-depth research on treatment plans related to abnormal glucose metabolism in RA.