Artemisia frigida Willd.: Advances in Traditional Uses, Phytochemical Constituents, Extraction and Separation Methods, and Pharmacological Activities

作者：Wei Tian, Mengjie Zhang, Tong‐Cun Zhang, Xianglong Li, Xianglong Li, Haiying Zhang, Xiumei Li, Xiumei Li · 发表于：Separations · 年份：2025 · DOI：10.3390/separations12100280 · 被引用次数：2 · 研究领域：Phytochemicals and Antioxidant Activities、Essential Oils and Antimicrobial Activity、Natural product bioactivities and synthesis

Artemisia frigida Willd. (A. frigida), a traditional medicinal herb widely distributed in northern China, Mongolia, and Siberia, has garnered increasing scientific interest due to its diverse phytochemical profile and extensive pharmacological potential. Modern studies have identified a wide range of bioactive compounds in A. frigida, including flavonoids, sesquiterpene lactones and phenolic acids. These compounds exhibit various biological activities, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. This review systematically summarizes the research progress on the chemical constituents of A. frigida and their extraction and separation methods, including solvent extraction, ultrasonic-assisted extraction, macroporous resin adsorption, and chromatography-based techniques. By integrating traditional knowledge with modern pharmacological evidence, this review provides a scientific foundation for the further development and utilization of A. frigida in functional food, pharmaceuticals, and ethnomedicine.