The role of three glucose/lipid composite indices (CHG, TYG, and AIP) in predicting carotid plaque and fatty liver outcomes: a retrospective cohort study

作者：Dan Li, Zhichao Xu, Feifei Wang, Yinqin Hu, Xinyu Zhang, Jiahui Yang, Qing Wan, Ning Zhang, Yongming Liu · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1686931 · 被引用次数：10 · 研究领域：Liver Disease Diagnosis and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins、Cardiovascular Health and Disease Prevention

Background Carotid plaque and fatty liver disease, as important target organ damages of metabolic disorders, have undergone a steady increase in prevalence. Cholesterol, high-density lipoprotein, and glucose index (CHG), triglyceride–glucose index (TYG), and atherogenic index of plasma (AIP) are tools for assessing metabolic abnormalities. This research aimed to evaluate the potential of three indicators in predicting carotid plaque and fatty liver. Methods This study is based on longitudinal health examination data from workers at Ansteel Group in China in 2019. The follow-up period was five years, with the outcomes being the occurrence of carotid plaque or fatty liver events. Multivariate Cox regression analysis was used to examine the relationship between CHG, TYG, and AIP with the outcomes of carotid artery plaque and fatty liver. We used restricted cubic spline (RCS) curves to analyze the dose-response relationship between the three indices and the outcomes. We employed receiver operating characteristic (ROC) curves to evaluate the predictive ability of these indices. Finally, we also conducted subgroup analyses. Results Carotid plaque events developed in 659 workers (18.40%), and fatty liver in 375 workers (10.47%) during the follow-up period. Cox analysis revealed that the three indices were correlated with carotid plaque (Q3 vs Q1, CHG: HR 2.13, P < 0.001; TYG: HR 1.20, P = 0.006; AIP: HR 1.95, P < 0.001) and fatty liver (Q3 vs Q1, CHG: HR 2.46, P &l...