Meta‐Analysis: Utilisation of Hepatocellular Carcinoma Surveillance

作者：Nicole K. Y. Tang, Shyna Gunalan, Christen En Ya Ong, Benjamin Koh, Ethan Kai Jun Tham, Ryan Yanzhe Lim, Darren Jun Hao Tan, Nicholas Syn, Cheng Han Ng, Mark Muthiah, Pojsakorn Danpanichkul, Karn Wijarnpreecha, Masahito Nakano, Asako Nogami, Atsushi Nakajima, Ming‐Hua Zheng, Kazuhiro Takahashi, Arndt Vogel, Mei Chin Lim, Daniel Q. Huang · 发表于：Alimentary Pharmacology & Therapeutics · 年份：2025 · DOI：10.1111/apt.70403 · 被引用次数：9 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Liver Disease and Transplantation、Liver Disease Diagnosis and Treatment

BACKGROUND AND AIMS: Major society guidelines recommend hepatocellular carcinoma (HCC) surveillance every 6 months with hepatic ultrasound. HCC surveillance is associated with early detection and improved survival but is underutilised. We aim to provide an updated assessment of HCC surveillance utilisation. METHODS: Ovid MEDLINE and Embase were searched from inception until 30 November 2023 to identify studies reporting the proportion of people with either cirrhosis or chronic hepatitis B who underwent ultrasound-based HCC surveillance. The primary objective was to determine the utilisation of HCC surveillance. A meta-analysis of proportions was conducted using a generalised linear mixed model. RESULTS: Forty-eight articles (1,275,349 individuals) met inclusion criteria. In at-risk individuals (cirrhosis or chronic hepatitis B), pooled utilisation of any HCC surveillance (n = 21 studies) was 54.45% (95% CI: 37.77-70.19), and utilisation of biannual surveillance (n = 7 studies) was 8.76% (95% CI: 2.46-26.79). Utilisation of any HCC surveillance was 53.37% (95% CI: 33.72-72.03) in patients with cirrhosis (n = 15 studies) and 66.43% (95% CI: 42.74-83.99) in patients with chronic hepatitis B (n = 12 studies), while utilisation of biannual surveillance was 10.20% (95% CI: 1.92-39.71) and 12.96% (95% CI: 0.02-99.09) respectively. Utilisation of surveillance did not improve over time. Pooled analysis of 40,497 individuals diagnosed with HCC (n = 27 studies) determined that the propo...