Dendritic Cell-Inspired Triple-Functional Biocatalysts with Atomic Iron Sites To Eradicate Drug-Resistant Bacteria and Biofilms

作者：Haoju Huang, Yang Gao, Xizheng Wu, Zhiying Ding, Junqiao Zhao, Qinlong Wen, Lan Xie, Tian Ma, Mao Wang, Chong Cheng, Weifeng Zhao, Changsheng Zhao · 发表于：ACS Nano · 年份：2025 · DOI：10.1021/acsnano.5c13477 · 被引用次数：6 · 研究领域：Advanced Nanomaterials in Catalysis、Bacterial biofilms and quorum sensing、Nanoplatforms for cancer theranostics

The global crisis of antimicrobial resistance demands solutions that transcend conventional antibiotic paradigms. Here, we present an atomically engineered VS 4 -based nanomaterial (TFB-Fe@VS 4 ) featuring dendritic architectures with single-iron catalytic sites, designed as a multimodal reactive oxygen species (ROS) generator against methicillin-resistant Staphylococcus aureus (MRSA) and its recalcitrant biofilms. This biocatalytic system leverages three synergistic mechanisms: nanodendrite-mediated bacterial capture, microenvironment-responsive ROS generation, and ultrasound-amplified oxidative burst, which collectively address the key challenges in eradicating drug-resistant infections. Structural and spectroscopic analyses reveal that atomic iron sites serve dual functions as peroxidase-mimetic catalytic sites and electronic structure modulators, significantly enhancing ultrasound-triggered ROS production through band engineering. The TFB-Fe@VS 4 achieves complete MRSA biofilm eradication and rapid wound sterilization in rabbit models with therapeutic outcomes similar to vancomycin yet without detectable inflammation or systemic toxicity. These findings present a design example for artificial biocatalysts that combines precise atomic engineering with multimodal antimicrobial action. The ability to simultaneously target bacterial adhesion, microenvironment adaptation, and on-demand ROS amplification presents transformative potential for treating resistant infections across...