Changes in Body Mass Index in Children and Adolescents Living With Human Immunodeficiency Virus in Europe and Thailand Starting Dolutegravir

作者：Elizabeth Chappell, Siobhan Crichton, Intira Jeannie Collins, G Valle, Charlotte Duff, Kate Edgar, Carlo Giaquinto, Charlotte Jackson, Ali Judd, Laura Mangiarini, John O’Rourke, Karen Scott, Claire Thorne, Tessa Goetghebuer, Marc Hainaut, Wivine Tremerie, Marc Delforge, Thomas Hoffmann, Sannie Brit Nordly, Marla B Braun, Vana Spoulou, Luisa Galli, Elena Chiappini, Catiuscia Lisi, Carlotta Montagnani, Elisabetta Venturini, Magdalena Marczyńska, Jolanta Popielska, Maria Pokorska‐Śpiewak, Agnieszka Ołdakowska, Konrad Zawadka, Magdalena Pluta, Małgorzata Doroba, Luminita Ene, María José Mellado, Luis Escosa, Milagros García López Hortelano, Talía Sainz, Carlos Grasa, Paula Rodríguez, José Tomás Ramos, Pablo Rojo, Luis Prieto, Cristina Epalza, Alfredo Tagarro, Sara Domínguez‐Rodríguez, Álvaro Ballesteros, Marta Illán, Arantxa Berzosa, Sara Guillén, Beatriz Soto, María Luisa Navarro, Jesús Saavedra, Mar Santos, Elena Rincón, David Aguilera, Begoña Santiago, Beatriz Lázaro Martín, Andrea López Suárez, Amanda Bermejo, María Penín, Jorge Martínez, Katie Badillo, Ana Belén Jiménez, Adriana Navas, Eider Oñate, Itziar Pocheville, Elisa Garrote, Elena Colino, Olga Afonso, Jorge Gómez Sirvent, M. González-Ripoll Garzón, Vicente Román, Raquel Angulo, Olaf Neth, Lola Falcón-Neyra, Pedro Terol, Juan Luis Santos, Álvaro Vázquez, Begoña Carazo, A. N. Medina, Francisco Lendínez, Mercedes Ibáñez, Estrella Peromingo, María Isabel Sánchez, Beatriz Ruiz, Ana Grande, Francisco José Romero, Carlos Pérez, Alejandra Méndez, Laura Calle-Miguel, V Rio, Marta Pareja, Begoña Losada, Mercedes Herranz, Matilde Bustillo Alonso, Pilar Collado, José Antonio Couceiro, Leticia Vila, Consuelo Calviño, Ana Isabel Piqueras, Manuel Oltra, César Gavilán, Elena Montesinos, Marta Dapena, Beatriz Jiménez, Ana Gloria Andrés, Víctor Marugán, Carlos Ochoa, Ana Isabel Menasalvas, Eloísa Cervantes, Cristina Díez, Ignacio Bernardino, Marisa Montes, Eulalia Valencia, Ana Sofia Delgado, Rafael Rubio, Federico Pulido, Otilia Bisbal, Alfonso Monereo Alonso, Juan Berenguer, Cristina Díez, Teresa Aldámiz, Francisco Tejerina, Juan Carlos Bernaldo de Quirós, Belén Padilla, Raquel Carrillo, Pedro Montilla, Elena Bermúdez, Maricela Valerio, José Sanz, Alejandra Gimeno, Miguel Cervero, Rafael Torres, Santiago Moreno, María Jesús Pérez-Granda, Santos del Campo, Pablo Ryan, Jesús Troya, Jesús Sanz, Juan Emilio Losa, Rafael Hervás Gómez, Miguel Górgolas, Alberto Díaz, Sara de la Fuente, José Antonio Iribarren, María José Aramburu, Lourdes Martínez, Ane Josune Goikoetxea, Sofía Ibarra, Mireia de la Peña, Víctor Asensi, Michele Hernández, María Remedios Alemán Valls, Ricardo Pelazas, María del Mar Alonso, Ana M. López, Dácil García, Jehovana Rodríguez, Miguel Ángel Cárdenes, Manuel A Castaño, Francisco Orihuela, Inés Pérez, M. Mayorga, Luís F. López‐Cortés, Cristina Roca, Silvia Llaves, María Rios, Jesús Rodríguez, Virginia Palomo, Juan Pasquau, Coral García, José L. Hernández, Clara Martínez, Antonio Rivero, Ángela Camacho, Dolores Merino, Miguel Raffo, Laura Corpa, Elisa Martínez, Fernando Mateos, José Javier Blanch, Miguel Torralba, Piedad Arazo, Gloria Sampériz, Celia Miralles, Antonio Ocampo, Guille Pousada, Álvaro Mena, Marta Montero, Miguel Salavert, Maria Jose Galindo, Natalia Pretel, Joaquín Portilla, Irene Portilla, Félix Gutiérrez, Mar Masiá, Cati Robledano, Araceli Adsuar, Carmen Hinojosa, Begoña Monteagudo, P Bachiller, Jésica Abadía, Carlos Galera, Helena Albendín, Marian Fernández, José Ramón Blanco, Pere Soler‐Palacín, Maria Antoinette Frick, Santiago Pérez‐Hoyos, Núria López, María Méndez, Clara Carreras, Borja Guarch-Ibáñez, Teresa Vallmanya, Laura Minguell-Domingo, Olga Calavia, Lourdes García, Maite Coll, Valentí Pineda, Neus Rius, Núria Rovira, Joaquín Dueñas, Clàudia Fortuny, Anna Gamell, Antoni Noguera‐Julián, Lars Navér, Nora Einarsson, Vendela Hagås, Johanna Rubin, Sandra Soeria‐Atmadja, Irène A. Abela, Karoline Aebi-Popp, A Anagnostopoulos, Manuel Battegay, M Baumann, Enos Bernasconi, Dominique Laurent Braun, Heiner C. Bucher, A Calmy, Matthias Cavassini, Angela Ciuffi, Pierre Alex Crisinel, Katharine Darling, G Dollenmaier, A Duppenthaler, Matthias Egger, Luisa Elzi, Jan Fehr, Jacques Fellay, Katyuska Francini, HJ Furrer, Christoph Andreas Fux, Huldrych F. Günthard, Anna Hachfeld, D Haerry, B Hasse, Hans H. Hirsch, Matthias Hoffmann, I H Hösli, Michael Huber, David Jackson-Perry, Christian R. Kahlert, Olivia Keiser, Thomas Klimkait, Malte Kohns, Lisa Kottanattu, Roger D. Kouyos, H Kovari, Katharina Kusejko, Niklaus Daniel Labhardt, Karoline Leuzinger, de Tejada Bm, Catja Marzolini, Karin J. Metzner, Nicolas Müller, Johannes Nemeth, Dunja Nicca, Julia Notter, P Paioni, Giuseppe Pantaleo, M Perreau, Christian Polli, Elisabetta Ranieri, Andri Rauch, Luisa Paola Salazar-Vizcaya, Patrick Schmid, Olivier Ségéral, Roberto F. Speck, M Stöckle, Philip Edward Tarr, Lecompte Marthe Than, Alexandra Trkola, Noémie Wagner, Gilles Wandeler, Maja Weisser, Sabine Yerly, Rachaneekorn Nadsasarn, Chutima Saisaengjan, Patama Deeklum, Phattharapa Khamkhen, Lucksanapon Pitikawinwong, Nattakarn Tantawarak, Pope Kosalaraksa, Chanasda Kakkaew, T Kaleeva, Y Baryshnikova, I Raus, O Glutshenko, Halyna Sherstiuk, Iryna Shkurka, Natalia Delikhovska, Iryna Popova, Tetiana Golubieva, Алла Волоха, Ruslan Malyuta, Claire Thorne · 发表于：Open Forum Infectious Diseases · 年份：2025 · DOI：10.1093/ofid/ofaf640 · 被引用次数：1 · 研究领域：HIV-related health complications and treatments、HIV/AIDS drug development and treatment、HIV/AIDS Research and Interventions

Abstract Background Excess weight gain has been reported in some adults on dolutegravir (DTG), but data in children/adolescents living with human immunodeficiency virus (CALHIV) are limited. Methods CALHIV aged 2–17 years at DTG start from 15 observational cohorts across Europe and Thailand were included. Mixed models described changes in body-mass-index-for-age z-score (zBMI). We assessed (1) zBMI change 48 weeks before versus after DTG start; (2) zBMI change up to 96 weeks on DTG and associated factors; and (3) zBMI changes over 96 weeks in CALHIV aged 6–17 years at start of DTG versus protease inhibitor (PI)–based regimens using propensity score weighting. Results Of 948 CALHIV on DTG (>99% HIV-1, <1% HIV-2), 50% were female, the median age was 13.7 (interquartile range [IQR], 11.1–15.6]) years, median zBMI was 0.31 (IQR, −0.64 to 1.19), 48% were Black, and 30% were overweight or obese at DTG start. Among 741 participants with zBMI available before and after DTG start, zBMI (95% confidence interval (CI) increased by 0.07 (.03–.11) versus 0.13 (.09–.16) (P = .087), in the 48 weeks before and after DTG start, respectively. Mean zBMI change by 96 weeks on DTG was 0.20 (95% CI .14–.27). In multivariable models, greatest increases in zBMI were in those aged 6–11 years at DTG start (0.34 [95% CI .23–.44]), males of “other” ethnicity (0.39 [95% CI .10–.68]), Black females (0.27 [95% CI .15–.39]), and those on tenofovir alafenamide (TAF) (0.39 [95% CI .17–.61]). Ther...