Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey

作者：Hamdi S Adam, Weihua Guan, Abigail J. Johnson, Sanaz Sedaghat, Charlene Enhui Goh, James S. Pankow, Ryan T. Demmer · 发表于：Journal of Periodontology · 年份：2025 · DOI：10.1002/jper.11395 · 被引用次数：5 · 研究领域：Oral microbiology and periodontitis research、Gut microbiota and health、Salivary Gland Disorders and Functions

BACKGROUND: Although periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease measures for CMD mortality in the National Health and Nutrition Examination Survey (NHANES). METHODS: We included 5,037 adults aged ≥30 years (mean age [± standard deviation (SD)]: 48[± 14]; 50% male) from the 2009-2010 and 2011-2012 NHANES cycles. We used 16S rRNA sequencing data from saliva to operationalize microbial composition and diversity. We calculated the relative abundance log-ratio of Treponema (linked with periodontal disease) to Corynebacterium (linked with periodontal health) to compute the Microbial Indicator of Periodontitis (MIP). Interproximal periodontal probing depth and clinical attachment loss were measured from periodontal examinations. Mortality was ascertained through 2019. Survey-weighted Cox models regressed mortality rates on MIP, microbial diversity, and periodontal measures to estimate hazard ratios and 95% confidence intervals (HR [95% CI]). RESULTS: Over 8.8 median follow-up years, there were 81 CMD and 267 all-cause deaths. After multivariable adjustment, MIP was associated with increased CMD mortality risk (HR per 1-SD: 2.10 [1.30-3.38]). Neither microbial diversity nor periodontitis measures were associated with CMD mortality. MIP was associated with periodontitis in multivariable modeling (risk ratio per 1-...