Quality of life in people with herpes zoster: a cross-sectional study in China

作者：Yang Shen, Yiqi Xia, Wenhui Zhu, Jing Ai, Chengsen Cui, Yemin Yuan, Lidan Wang, Wenqiang Yin, Zhenyu Shi, Ping He · 发表于：Health and Quality of Life Outcomes · 年份：2025 · DOI：10.1186/s12955-025-02435-2 · 被引用次数：2 · 研究领域：Herpesvirus Infections and Treatments、Cytomegalovirus and herpesvirus research、Facial Nerve Paralysis Treatment and Research

INTRODUCTION: Herpes zoster (HZ), affecting 14.9 million people aged ≥ 50 globally in 2020, imposes a growing burden in aging populations due to its association with chronic pain, psychological distress, and socioeconomic disparities. This study aimed to evaluate health-related quality of life (HRQoL) among people with HZ and explore its socioeconomic and clinical determinants in China. METHODS: We conducted a cross-sectional survey to investigate the HRQoL of 2,566 herpes zoster patients across seven Chinese cities using the EQ-5D-5 L and VAS-100 instruments. Multivariate linear regression models quantified the association of age, income, insurance type, herpes zoster related pain, complications, and comorbidities with HRQoL. RESULTS: The average EQ-5D score was 0.83, and the average VAS score was 71.49 among herpes zoster patients in China. Patients aged ≥ 70 years exhibited the most severe decline in both EQ-5D (β = -0.110, p < 0.01) and VAS-100 scores (β = -8.811, p < 0.01), with mobility limitations (OR = 3.696, p < 0.01) and self-care deficits (OR = 2.295, p < 0.01) disproportionately affecting this group. Herpes zoster related pain was associated with lower HRQoL (EQ-5D:β = -0.126, p < 0.01). Patients with comorbidities faced significant HRQoL reductions (VAS: β = -4.014, p < 0.01). CONCLUSION: Our study found that Chinese herpes zoster patients exhibited higher HRQoL scores compared to those reported in most of other studies. Advanced age, lower education levels, inad...