Health-related quality of life and influencing factors in parents of children with congenital heart disease: a systematic review and meta-analysis

作者：Yu Wang, Fang Ma, Jingran Yang, Yimei Zhang, Min Zhou, Yangjuan Bai, Majd Elmobasher, Zhisong Chen · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1622491 · 被引用次数：2 · 研究领域：Congenital Heart Disease Studies、Family and Disability Support Research、Cardiovascular Issues in Pregnancy

Introduction Parents of children with congenital heart disease (CHD) have been described as ‘hidden patients,’ which negatively impacts their health-related quality of life (HRQoL). The extent of HRQoL impairment among parents of children with CHD and its contributing factors remain controversial. This systematic review and meta-analysis aimed to systematically examine the HRQoL in parents of children with CHD and sought to determine the influencing factors. Methods A comprehensive search for articles was performed via CINAHL, Embase, PsycINFO, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical (Sinomed), Weipu (VIP), and Wanfang databases from the establishment of the database to September 30, 2024. Cross-sectional, cohort and case–control studies, evaluating the HRQoL or influencing factors for parents of children with CHD were identified and collected. Results Of the 4,013 studies identified, one cohort study and 22 cross-sectional studies comprising 3,681 parents of children with CHD were included. Pooled results indicated that in each domain of the Short Form-36 Health Survey (SF-36), the HRQoL scores for general health (SMD, −0.58; 95% CI, −0.79, −0.37; p < 0.001), role difficulty due to emotional problems (SMD, −0.79; 95% CI, −1.00, −0.58; p < 0.001), role difficulty due to physical problems (SMD, −0.31; 95% CI, −0.52, −0.11; p = 0.003), and social function domains (SMD, −0.53; 95% CI, −0.74, −0.33; p < 0.001...