Effects of Exercise Interventions on Chemotherapy-Induced Peripheral Neuropathy-Related Pain in Patients With Cancer

作者：Xinyu Wu, Jianxin Li, Yiting Yang, Yajun Dong, Liping Teng · 发表于：Cancer Nursing · 年份：2025 · DOI：10.1097/ncc.0000000000001546 · 被引用次数：2 · 研究领域：Cancer Treatment and Pharmacology、Cancer survivorship and care、Pain Management and Opioid Use

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN)-related pain seriously affects patients' quality of life (QoL). Previous studies have shown that exercise interventions can improve symptoms such as pain in patients with CIPN. However, the optimal exercise intervention remains unknown. OBJECTIVE: To explore the comparative effects and ranks of all exercise-based interventions in improving CIPN-related pain, CIPN symptoms, and QoL in cancer patients experiencing CIPN. METHODS: We searched 10 electronic databases to identify randomized controlled trials from their inception up to June 23, 2024. We used Review Manager 5.4.1 and Stata v14.0 for traditional meta-analysis and network meta-analysis (NMA). RESULTS: This review included 14 randomized controlled trials with a total of 1127 participants. The NMA revealed that: (a) a combination of strengthening, stretching, and balance exercises (standardized mean difference [SMD] = -11.43, 95% confidence interval [CI], -13.60 to -9.26) was the most effective intervention for improving CIPN-related pain; (b) walking exercise (SMD = -2.07, 95% CI, -2.70 to -1.43) yielded better outcomes in alleviating CIPN symptoms; and (c) interventions focused on muscle strengthening and balancing exercises (SMD = 1.03, 95% CI, 0.40 to 1.65) were most effective for improving QoL. CONCLUSIONS: Our NMA indicated that strengthening, stretching, and balance exercises could potentially benefit the improvement of CIPN-related pain. Further eviden...