A thermo-sensitive peptide hydrogel loaded with paclitaxel and antimony nanosheets for synergistic photothermal-chemotherapeutic treatment of breast cancer

作者：Bo Yan, Ling Gu, Hajra Zafar, Aiping Shi, Hong Ge, Jin Yu, Nan Wang, Miao Wang, Binbin Liu, Yiqun Wu, Tianli Tian, Rongjie Ding · 发表于：Frontiers in Pharmacology · 年份：2025 · DOI：10.3389/fphar.2025.1681276 · 被引用次数：5 · 研究领域：Nanoplatforms for cancer theranostics、Hydrogels: synthesis, properties, applications、Cancer Research and Treatment

Introduction: Breast cancer is one of the most common cancers in the world. Paclitaxel (PTX), a potent chemotherapeutic agent, is widely used in cancer treatment but suffers from poor aqueous solubility and systemic toxicity. Methods: In this study, we developed a thermo-sensitive peptide, TSP-5, which forms a stable hydrogel at 37 °C and dissociates upon heating to 45 °C to facilitate drug release. The hydrogel was co-loaded with PTX and photothermal agent antimony nanosheets (AM) for targeted delivery to tumor sites. Under near-infrared (NIR) laser irradiation, AM rapidly elevated the local temperature due to its high photothermal conversion efficiency, triggering hydrogel dissolution and subsequent PTX release. Simultaneously, AM-mediated photothermal therapy (PTT) contributed to tumor cell ablation. Results: studies demonstrated that the TSP-5 hydrogel significantly enhanced PTX solubility, reduced systemic toxicity, and improved anti-tumor efficacy. Discussion: The findings highlight its potential as a promising platform for localized drug delivery.