Association between pan-immune-inflammation value and bone turnover markers in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study

作者：Jiahao Wang, Mingyang Zhu, Chong Li, Guohua Wang, Ke Lü, Yan-ming Hao · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1660376 · 被引用次数：4 · 研究领域：Bone health and osteoporosis research、Inflammatory Biomarkers in Disease Prognosis、Parathyroid Disorders and Treatments

Background Systemic inflammation has been linked to impaired bone remodeling and may contribute to the risk of osteoporotic fractures (OPFs). This study examined the relationship between baseline pan-immune-inflammation value (PIV) and bone turnover markers (BTMs) in patients hospitalized for the surgical treatment of OPFs. Methods In this retrospective cross-sectional study, 839 patients aged ≥50 years who were treated for osteoporotic fragility fractures between 2017 and 2024 were analyzed. PIV was calculated as (neutrophils × platelets × monocytes)/lymphocytes. BTMs included serum β -C-terminal telopeptide of type I collagen (β-CTX) and procollagen type I N-terminal propeptide (P1NP). Associations between log₂-transformed PIV and BTMs were assessed using multivariable generalized estimating equations (GEEs), adjusting for demographic, clinical, and biochemical factors. Smoothing spline models and threshold effect analyses were used to explore potential non-linear relationships. Subgroup analyses were conducted to examine effect modification. Results The mean age of participants was 69.4 ± 10.9 years, with 70.9% being female. Mean β -CTX and P1NP levels were 0.54 ± 0.29 ng/mL and 58.1 ± 35.3 ng/mL, respectively, and the mean log₂PIV was 8.24 ± 1.28. Higher PIV levels were independently associated with lower BTMs. Specifically, each doubling of PIV was associated with a 4.46 ng/mL reduction in P1NP and a 0.05 ng/mL reduction in β -CTX (both p < 0.001). An inverted J-s...