Population Genomics and Antimicrobial Resistance trends of Emerging Salmonella Aberdeen Clones Circulating among Humans and Seafood

作者：Abubakar Siddique, Guimin Gu, Jianxin Ye, Guangzhi Zhang, Abdul Raheem, Jia Li, Xuebin Xu, Min Yue · 发表于：Journal of Future Foods · 年份：2025 · DOI：10.1016/j.jfutfo.2025.08.014 · 被引用次数：2 · 研究领域：Salmonella and Campylobacter epidemiology、Vibrio bacteria research studies、Viral gastroenteritis research and epidemiology

• S . Aberdeen is an emerging pathogen identified in both food and non-food sources. • ST426 was the predominant sequencing type within S . Aberdeen population. • A few antimicrobial resistance genes were identified among the examined isolates. • Human isolates were genetically related to seafood and environmental isolates. Salmonella Aberdeen ( S . Aberdeen) is an underestimated emerging foodborne pathogen with potential public health significance; however, global efforts in understanding antimicrobial resistance (AMR) and population genomics within S . Aberdeen population remain unaddressed. Here, we performed whole genome sequencing (WGS) on six S . Aberdeen isolates obtained from diarrheal patients (n=3) and seafood (n=3). Additionally, 102 publicly available S . Aberdeen genomes, retrieved from NCBI and EnteroBase and isolated from various sources across 14 countries between 1938 and 2023, were collated for genomic analysis. All 108 genomes were analyzed to investigate AMR determinants, virulence factors, heavy metal resistance genes (HMRGs), sequence types, plasmid content, and phylogenetic relationships. WGS analysis revealed that the majority of isolates (95%, 103/108) belonged to sequence type ST426, suggesting a monophyletic population. High multi-drug resistance (MDR) (66.67%) and resistance to fourth-generation cephalosporins were found in isolates from seafood (66.67%) and humans (33.3%). Three antimicrobial resistance genes (ARGs) bla TEM-1C, aac(6)-laa , and fo...