Tailoring treatment to cancer risk and patient preference: the 2025 St Gallen International Breast Cancer Consensus Statement on individualizing therapy for patients with early breast cancer

作者：Harold J. Burstein, Giuseppe Curigliano, Michael Gnant, Sibylle Loibl, Meredith M. Regan, Sherene Loi, C. Denkert, Philip Poortmans, David Cameron, Beat Thürlimann, William P. Weber, Stefan Aebi, Meteb Al-Foheidi, Zsuzsanna Bago-Horvath, Francois-Clement Bidard, Judy Boughey, Denisse Bretel Morales, Sara Brucker, Harold J. Burstein, David Cameron, Maria-Joao Cardoso, Lisa Carey, Stephen Chia, Charlotte Coles, Javier Cortes, Giuseppe Curigliano, Shaheenah Dawood, Jana de Boniface, Angela Demichele, Carsten Denkert, Gerd Fastner, Prudence Francis, Viviana Enrica Galimberti, Hebatallah Gamal Mahmoud, Armando Giuliano, Michael Gnant, M. Bahadir Gulluoglu, Nadia Harbeck, Chiun-Sheng Huang, Jens Huober, Wolfgang Janni, Komal Jhaveri, Zefei Jiang, Orit Kaidar-Person, Virginia Kaklamani, Kevin Kalinsky, Daniela Kauer-Dorner, Catherine M. Kelly, Sung Yong Kim, Marleen Kok, Matteo Lambertini, Sherene Loi, Sibylle Loibl, Eleftherios Mamounas, Kelly Metcalfe, Laura Michel, Monica Morrow, Anusheel Munshi, Mafalda Oliveira, Shani Paluch-Shimon, Martine Piccart, Barbara Pistilli, Philip Poortmans, Shelley Potter, Meredith Regan, Isabel, Rubio, Hope S. Rugo, Shigehira Saji, Cristina Saura Manich, Elżbieta Senkus, Zhiming Shao, Christian Singer, Christine Solbach, W. Fraser Symmans, Christoph Tausch, Beat Thürlimann, Eriko Tokunaga, Nicholas Turner, Andrew Tutt, Cicero Urban, Marcus Vetter, Cynthia Villarreal-Garza, Marie Jeanne Vrancken Peeters, Walter Weber, Hans Wildiers, Binghe Xu, Yongmei Yin · 发表于：Annals of Oncology · 年份：2025 · DOI：10.1016/j.annonc.2025.09.007 · 被引用次数：36 · 研究领域：Breast Cancer Treatment Studies、Advanced Breast Cancer Therapies、Breast Lesions and Carcinomas

BACKGROUND: Breast cancer is a global disease affecting millions of individuals. Ongoing advancements in multidisciplinary management of breast cancer patients warrant discussion and integration into standard treatment plans. DESIGN: The St Gallen Breast Cancer Consensus conference is an international, biennial meeting where experts make treatment recommendations for state-of-the-art care of early stage breast cancer. RESULTS: Important innovations in the 2025 St Gallen recommendations include updated guidance on genetic testing; endorsement of hypofractionated, and ultra-hypofractionated, radiation therapy schedules for larger numbers of patients; recommendation for platinum-based chemotherapy in triple-negative breast cancer, and use of biological risk markers to consider anthracyclines in other breast cancer subtypes; avoidance of sentinel lymph node surgery in many patients with low-risk, estrogen receptor (ER)-positive cancers; use of immunotherapy in triple-negative and certain ER low-positive tumors; guidance for re-irradiation and systemic therapy in the setting of local-regional recurrence; criteria to guide treatment of oligometastatic breast cancer; and important recommendations for improving survivorship by minimizing neuropathy symptoms and addressing sexual health concerns of breast cancer patients. CONCLUSIONS: International, multidisciplinary guidance for early breast cancer is evolving and offers patients better outcomes, improved treatment choices, and great...