Association between longitudinal weight change and clinical outcome in individuals with MASLD

作者：Yu Shi, Ruoqi Zhou, Seung Up Kim, Terry Cheuk‐Fung Yip, Emmanuel Tsochatzis, Salvatore Petta, Atsushi Nakajima, Hannes Hagström, Elisabetta Bugianesi, Wah‐Kheong Chan, Jérôme Boursier, George Boon‐Bee Goh, Arun J. Sanyal, Manuel Romero‐Gómez, José Luís Calleja, Victor de Lédinghen, Philip N. Newsome, Jian-Gao Fan, Michelle Lai, Laurent Castéra, Céline Fournier‐Poizat, Hye Won Lee, Grace Lai‐Hung Wong, Grazia Pennisi, Masato Yoneda, Ying Shang, Angelo Armandi, Marc de Saint-Loup, Clémence M. Canivet, Kevin Kim‐Jun Teh, Amon Asgharpour, Rocío Gallego‐Durán, Elba Llop, Carmen Lara‐Romero, Mandy Sau-Wai Chan, Mirko Zoncapè, Huapeng Lin, Wen‐Yue Liu, Giovanni Targher, Christopher D. Byrne, Vincent Wai‐Sun Wong, Ming‐Hua Zheng, on behalf of the VCTE-Prognosis Study Group · 发表于：Hepatology · 年份：2025 · DOI：10.1097/hep.0000000000001557 · 被引用次数：15 · 研究领域：Liver Disease Diagnosis and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins、Liver Disease and Transplantation

BACKGROUND AND AIMS: Weight control remains the cornerstone for metabolic dysfunction-associated steatotic liver disease (MASLD) management. We assessed the relationships between dynamic weight change and the risk of liver-related events (LREs) and liver stiffness changes in MASLD. APPROACH AND RESULTS: By enrolling adult MASLD individuals with ≥2 weight measurements from 16 tertiary referral centers, we assessed how longitude weight change, including the following categories (stable ≤5% change, weight loss >5% decrease, weight gain >5% increase) and changing status of obesity (persistent non-obesity, persistent obesity, transition from non-obesity to obesity, transition from obesity to non-obesity), were associated with LREs. Analyses were undertaken with multivariable linear regressions, Cox proportional hazards regression, and logistic regression, adjusting for age, sex, ethnicity, baseline BMI, hypertension, T2D, LSM, CAP, and SGLT-2i/GLP-1RAs usage. Analyses between weight change and liver stiffness change were also undertaken. A total of 10,014 MASLD individuals with ≥2 weight measurements were included. Over a measurement interval of 29.2 months, 123 LREs occurred during 12.4 months of follow-up after the final weight assessment. Weight gain >5% was associated with increased risk of LREs [aHR=1.84 (95% CI: 1.01-3.09), p =0.020] and liver stiffness progression [aOR=2.07 (95% CI: 1.55-2.74), p <0.001], while weight loss >5% exhibited liver stiffness improvement. Although...