Marked Variation in Hepatic Steatosis in Metabolic Dysfunction‐Associated Steatotic Liver Disease Over 5 Years: A Community‐Based Study Using Controlled Attenuation Parameter

作者：Marta Cervera, Martina Pérez, Marta Carol, Ruth Nadal, Maria Sanz‐Rodríguez, Adrià Juanola, Anna Sòria, Rosario Lunar Hernández, Gemma Sáez, Míriam Pellón, Queralt Herms, Elisa Pose, Pere Ginès, Isabel Graupera, Núria Fabrellas · 发表于：United European Gastroenterology Journal · 年份：2025 · DOI：10.1002/ueg2.70099 · 被引用次数：2 · 研究领域：Liver Disease Diagnosis and Treatment、Nutrition and Health in Aging、Liver Disease and Transplantation

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is very common and associated with significant morbidity and mortality due to its potential progression to cirrhosis and liver cancer. Whereas hepatic fat accumulation is the key to MASLD progression, little is known regarding changes in liver fat content over time in the general population. We aimed to investigate changes in liver fat in a longitudinal study of the general population. METHODS: We conducted a longitudinal study involving 195 randomly selected individuals from the general population, evaluated at two time points, 5 years apart. Participants with hepatic steatosis at baseline did not receive any specific treatment. The primary objective was to assess changes in liver fat content, as estimated by controlled attenuation parameter (CAP) using transient elastography. We also examined the frequency of steatosis resolution and development. CAP variability was assessed in two measurements 7 days apart in a cross-sectional study of 101 volunteers, with a mean variability of 9.9%. Steatosis resolution was defined as reduction of CAP > 10% from baseline with a final value < 275 dB/m, while steatosis development was defined as increase in CAP > 10% with a final value ≥ 275 dB/m. RESULTS: Remarkable variations in liver fat content were observed. Among the 88 participants with steatosis at baseline, 34% had resolution of steatosis (CAP decreased from 300 to 237 dB/m; p < 0.001). Resolution was asso...