Self-Amplifying Metal–Covalent Organic Framework for Programmable Antibacterial-Regenerative Therapy via ROS Cascades

作者：Ya Hu, Lin Xiao, M.C. Zang, Jinhong Zhang, Yan Jiang, Yanmin Zhang, Liuya Wei, Jibin Wang, Zhicui Liu, Junhui Zhao · 发表于：ACS Applied Polymer Materials · 年份：2025 · DOI：10.1021/acsapm.5c02395 · 被引用次数：5 · 研究领域：Nanoplatforms for cancer theranostics、Covalent Organic Framework Applications、Advanced Nanomaterials in Catalysis

Herein, we present an infection microenvironment (IME)-adaptive covalent organic framework (COF), termed Cu–B–COF, engineered through dynamic assembly of a bidentate N -substituted salicylimine-Cu complex [Cu(SALANIH-boronic acid) 2 ] and 5,10,15,20-tetrakis(2,3-dihydroxyphenyl)porphyrin. Cu–B–COF, integrating the characteristics of both metal–organic frameworks (MOFs) and COFs, could be used as a therapeutic agent for infectious wound healing. This intelligent platform features pH/H 2 O 2 -responsive boronate esters, enabling structural reconfiguration, followed by size switching and biodegradability. The Cu-based catalytic centers enable glutathione peroxidase-like (GPx-like) and peroxidase-like (POD-like) activities. Notably, the bidentate salicylimine-Cu units induce a spatial twisted three-dimensional structure, allowing efficient utilization of light energy, promoting both photothermal conversion and photodynamic processes while minimizing losses due to aggregation-induced quenching. As a result, Cu–B–COF exhibits superior photothermal conversion efficiency compared to its porphyrin precursor, while simultaneously demonstrating dual-modal photodynamic capabilities (Type I/II mechanisms), enabling self-adapting therapeutic cascades through three distinct operational phases. The synergistic glutathione (GSH) depletion and photothermal-potentiated POD-mimetic cycling cooperatively amplify hydroxyl radical (•OH) burst and ROS storm generation, enabling deep-tissue pathogen ...