Metabolic syndrome increases the risk of suicide attempt: evidence from a population-based cohort and genomic analysis

作者：Zhengyang Zhao, Min Xie, Shiwan Tao, Qiuyue Lv, Jiashuo Zhang, Jiachang Cai, Yunjia Liu, Yunqi Huang, Siyi Liu, Yulu Wu, Qiang Wang · 发表于：Translational Psychiatry · 年份：2025 · DOI：10.1038/s41398-025-03575-1 · 被引用次数：4 · 研究领域：Suicide and Self-Harm Studies、Cannabis and Cannabinoid Research、Poisoning and overdose treatments

Suicide is a critical global public health issue, where traditional risk assessment tools have limited predictive value, warranting the identification of novel risk assessment factors. Metabolic syndrome (MetS) has been linked to poor cognition and brain volumes, which may lead to abnormal behaviors. The relationship between MetS and suicide risk has been less studied. This study aims to explore the association of MetS on suicide attempt leveraging data from the UK Biobank and genomic analyses. We first explored the cross-sectional and longitudinal relationships between MetS and suicide attempt, while also exploring the mediating role of cognitive performance. Second, using summary data from the largest genome-wide association studies, the genetic associations between MetS, suicide attempt, and cognitive performance were examined. Of 380,557 participants tracked over 13 years, we identified 1847 new cases of suicide attempt. The presence of MetS was found to significantly increase the risk of suicide attempt (HR = 1.250, 95% CI = 1.134-1.379). In participants lacking traditional suicide risk factors, such as being female, younger, and having higher educational attainment, MetS still presented a greater risk in predicting future suicide attempts. Additionally, MetS and suicide attempt exhibited significant genetic correlation (rg = 0.080 ± 0.026), and Mendelian randomization analysis suggested MetS had a significant negative effect on suicide attempt (β = 0.156, 95% CI = 0.077...