Probiotic supplementation during pregnancy or infancy for the prevention of allergic rhinitis in infants: A systematic review and meta-analysis of Randomized controlled trials

作者：Zhengxiu Xiao, Haiqin Luo, Hao Liu, Hui Chen, Jun Bai, Wang Liao, Shi Wu Wen, Daniel Krewski, Huiling Shang, Ri‐hua Xie · 发表于：World Allergy Organization Journal · 年份：2025 · DOI：10.1016/j.waojou.2025.101124 · 被引用次数：4 · 研究领域：Probiotics and Fermented Foods、Gut microbiota and health、Infant Health and Development

Background: Early-life gut microbial colonization is crucial for immune system development, but the efficacy of probiotic interventions during pregnancy or infancy in preventing allergic rhinitis (AR) and atopic sensitization (AS) remains unclear. This systematic review synthesized evidence from randomized controlled trials (RCTs) assessing probiotics for AR and AS prevention. Methods: Seven English and Chinese databases were systematically searched up to February 13, 2025. Eligible studies were RCTs with clearly defined probiotic interventions and specified AR or AS outcomes. Risk of bias was assessed using the Cochrane tool. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using fixed-effects models. Results: = 0.03). Probiotics were also associated with transient increases in the abundance of targeted gut microbial strains. Conclusion: Probiotics during pregnancy and/or infancy may reduce AS odds in children over 1 year and correlate with age-related changes in gut microbial composition but failed to reduce AR odds at any age.