Indopexines A and B: Two Prenylated Isoindoline Alkaloids from the Fungus Aspergillus sp. TJ507

作者：Yeting Zhang, Yeting Zhang, Qiang Li, Zhengyi Shi, Xueqi Lan, Jinlong Zhang, Ming Chen, Xinye Huang, Kuansong Wang, Changxing Qi, Yonghui Zhang, Yonghui Zhang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03829 · 被引用次数：1 · 研究领域：Cancer Treatment and Pharmacology、Microbial Natural Products and Biosynthesis、Synthesis and pharmacology of benzodiazepine derivatives

Indopexines A ( 1 ) and B ( 2 ), two prenylated isoindoline alkaloids, were isolated from Aspergillus sp. TJ507. Their structures were determined by extensive spectroscopic analysis, CASE algorithms, quantum 1 H and 13 C NMR DP4+, and electronic circular dichroism calculations. Structurally, 1 was the first examples of isoindoline alkaloids bearing a 6/5/5/6 ring based on the 2-oxa-10-azatetracyclo-[7.7.0.0 1,12 .0 3,8 ]cetane core, while 2 featured an 5,20-bioxa-1-azapencyclo-[10.7.1.0 1,12 .0 6,11 .0 13,18 ]lcosane moiety. Furthermore, 1 displayed an inhibitory effect toward triple-negative breast cancer cells through the Rap1/PI3K/AKT signaling pathway.