Changes in accelerated aging and risk of cardiovascular disease and mortality: three cohort studies

作者：Jijuan Zhang, Hancheng Yu, Tingting Geng, Shuohua Chen, Yuxiang Wang, Huan Guo, Xiao-Min Zhang, Meian He, Jing-Li Gao, Gang Liu, Yun-Fei Liao, Shouling Wu, An Pan · 发表于：BMC Medicine · 年份：2025 · DOI：10.1186/s12916-025-04365-8 · 被引用次数：5 · 研究领域：Aging and Gerontology Research、Genetics, Aging, and Longevity in Model Organisms、Health disparities and outcomes

BACKGROUND: Accelerated aging is a dynamic process, yet few studies examined the association of changes in accelerated aging with cardiovascular disease (CVD) and mortality. This study aims to evaluate this association in three prospective cohorts from China and the UK. METHODS: Data were drawn from the Kailuan cohort (n = 107,830), the Dongfeng-Tongji (DFTJ) cohort (n = 14,032), and the UK Biobank (n = 316,087). Accelerated aging was assessed by PhenoAge and Klemera-Doubal method (KDM) age, measured at baseline (Kailuan cohort: 2006-2009; DFTJ cohort: 2008-2010; UK Biobank: 2006-2010) and the first follow-up (Kailuan cohort: 2010-2013; DFTJ cohort: 2013; UK Biobank: 2012-2013). Changes in accelerated aging were classified as persistent accelerated aging, recovery from accelerated aging, delayed accelerated aging, and stable non-accelerated aging. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Meta-analysis was performed to summarize estimates across three cohorts. RESULTS: Median follow-up periods were 10.3-15.9 years across three cohorts. When defining accelerated aging by PhenoAge, baseline accelerated aging was significantly associated with increased risks of CVD (pooled HR: 1.41, 95% CI: 1.25, 1.60) and mortality (pooled HR: 1.47, 95% CI: 1.33, 1.63). Compared to participants with persistent accelerated aging, participants recovering from accelerated aging (pooled HR of CVD: 0.76, 95% CI: 0.72, 0.81; pooled HR...