Persistence and clearance of oral human papillomavirus among a multi-national cohort of men

作者：Brittney L. Dickey, Racheal S. Dube Mandishora, Bradley Sirak, Wenyi Fan, Kimberly Isaacs‐Soriano, Richard R. Reich, Michael J. Schell, Eduardo Lazcano‐Ponce, Luisa L. Villa, Anna R. Giuliano · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-62963-9 · 被引用次数：3 · 研究领域：Head and Neck Cancer Studies、Cervical Cancer and HPV Research、Cleft Lip and Palate Research

In response to the growing burden of HPV-associated oropharyngeal cancer, this study investigated clearance of oral HPV, the obligate precursor, in a longitudinal cohort of men from the US, Brazil, and Mexico. Oral gargles collected every 6 months from the HPV Infection in Men Study were HPV genotyped using SPF10 PCR-DEIA-LiPA25. Oral HPV infection clearance and associated factors were assessed using Kaplan-Meier curves and Cox proportional hazards models, respectively. Median follow-up was 44.8 months with 403 and 186 men with an incident and prevalent oral HPV infection, respectively; and lower probability of clearance observed in prevalent infections. Infections were less likely to clear in the presence of increased sexual behaviors; and among prevalent infections, older men were less likely to clear their infection. Here, we report differences in prevalently and incidently detected infections with sexual behavior as a key factor and older age as a potential factor associated with clearance. Human papillomavirus (HPV)-associated oropharyngeal cancer is increasing but the natural history of oral HPV infection is not well understood. Here, the authors investigate clearance of oncogenic oral HPV infection in a cohort of men from the US, Brazil, and Mexico.