Classification of Elderly Patients with Comorbidities and Their Subtypes: A Data-Driven Cluster Analysis

作者：Xiuqi Qiao, Xinda Chen, Weihao Wang, Lixin Guo, Qi Pan · 发表于：Clinical Interventions in Aging · 年份：2025 · DOI：10.2147/cia.s549148 · 被引用次数：3 · 研究领域：Chronic Disease Management Strategies、Heart Failure Treatment and Management、Machine Learning in Healthcare

Background: To explore the precise classification of elderly patients with multimorbidity and identify subgroups with an increased prevalence of related diseases. Methods: A data-driven clustering analysis (K-means clustering) was conducted on individuals aged 60 years or older with comorbidities. The clustering was based on five essential and routinely measured variables: body mass index (BMI), intrinsic capacity (IC), low-density lipoprotein cholesterol (LDL-c), fasting plasma glucose (FPG), and systolic blood pressure (SBP). Logistic regression models were used to compare the prevalence of diabetes, coronary heart disease, hypertension, osteoporosis, sarcopenia, and frailty among the clusters. Results: A total of 350 elderly patients with a mean age of 78.74 ± 8.27 years were included. Four subtypes of elderly patients with multimorbidity were identified, with significant differences in disease prevalence observed among the groups. Specifically, cluster 1 included 70 participants who exhibited the highest levels of LDL-c and BMI, as well as relatively higher IC scores. Cluster 2 consisted of 117 participants, who had the highest IC scores among all clusters and similar BMI levels to cluster 1. Cluster 3 included 77 participants and was distinguished by the highest SBP levels. Cluster 4, comprising 86 participants, had the lowest IC and BMI levels. Compared with cluster 2, cluster 4 had significantly higher prevalence of hypertension and frailty. Cluster 3 and 4 had higher ...