Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases

作者：Yuhan Wang, Pengzhi Bu, Yu Deng, Wu Zhao, Guangtao Pan · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1629288 · 被引用次数：4 · 研究领域：Psoriasis: Treatment and Pathogenesis、melanin and skin pigmentation、Dermatology and Skin Diseases

Background: Autoimmune-related skin diseases such as psoriasis, atopic dermatitis (AD), vitiligo, and Sjögren's syndrome (SjS) are characterized by chronic inflammation, immune dysregulation, and complex pathogenesis. Current therapeutic options are limited by side effects, poor efficacy, and high costs. Traditional Chinese medicine (TCM) compounds have demonstrated promising immunomodulatory, anti-inflammatory, and antioxidant effects, offering a novel alternative for managing these conditions. Objective: To systematically review the pharmacological activities and therapeutic potential of bioactive compounds derived from traditional Chinese medicine in treating autoimmune-related skin diseases. Methods: A comprehensive literature review was conducted, focusing on studies that investigated the efficacy, mechanism, and delivery strategies of TCM-derived compounds. Diseases covered include psoriasis, AD, vitiligo, and SjS. Mechanistic pathways such as JAK/STAT, PI3K/AKT, and NF-κB were evaluated alongside compound-specific delivery systems. Results: Numerous TCM compounds, including curcumin, resveratrol, baicalein, berberine, ginsenosides, and paeoniflorin, exhibited therapeutic effects in preclinical and clinical models. These effects were mediated through various pathways, including inhibition of pro-inflammatory cytokines, restoration of skin barrier function, and modulation of immune cell balance. Nano-based delivery systems further enhanced the stability and bioavailabili...