Association between depression and metabolic dysfunction-associated steatotic liver disease: a cross-sectional analysis from the paracelsus 10,000 Study

作者：Florian Koutny, Vanessa Frey, Christian Datz, Sophie Gensluckner, Julian Prosenz, Patrick B. Langthaler, A Maieron, Maria Flamm, Daniel Weghuber, Bernhard Iglseder, Eugen Trinka, Bernhard Paulweber, Elmar Aigner, Bernhard Wernly · 发表于：Hepatology International · 年份：2025 · DOI：10.1007/s12072-025-10922-3 · 被引用次数：7 · 研究领域：Liver Disease Diagnosis and Treatment、Diabetes Management and Education、Hepatitis C virus research

BACKGROUND AND AIMS: Depression is linked to obesity and metabolic syndrome, but its independent association with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. We examined the association between depressive symptoms and MASLD, independent of other risk factors. METHODS: We analyzed cross-sectional data from 7433 participants of the Paracelsus 10,000 study. Depression (BDI-II > 13) and MASLD (FLI ≥ 60 plus ≥ 1 cardiometabolic risk factor) were assessed. Associations were examined using Poisson and linear regression models adjusted for demographics, lifestyle factors, metabolic syndrome, and antidepressant use. Subgroup and interaction analyses explored effect modification. RESULTS: MASLD was more prevalent in participants with depressive symptoms than those without (37% vs. 27%, p < 0.01). Depressive symptoms were independently associated with MASLD (adjusted incidence rate ratio: 1.25, 95% CI: 1.13-1.39, p < 0.01), with consistent findings using continuous BDI-II scores. The association remained robust across subgroups defined by age, metabolic syndrome, education, smoking status, and antidepressant use. No significant differences were observed in fibrosis markers (APRI and FIB-4). CONCLUSION: In this large, population-based cross-sectional study, depressive symptoms were found to be associated with MASLD, independent of metabolic risk factors and antidepressant use. However, given the observational design and limited detail on antidepressa...