HIF-1-mediated macrophage metabolic reprogramming promotes AKI to CKD transition

作者：Hong Ding, Yan Zhou, Ren-He Zhu, Shu‐Hong Yu, Aiqing Zhang, Hong Liu, Jialing Ji, Zuo‐Lin Li · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.111238 · 被引用次数：11 · 研究领域：Pancreatic function and diabetes、Cancer, Hypoxia, and Metabolism、Metabolism and Genetic Disorders

. Taken together, our studies provide a novel paradigm in which pro-inflammatory macrophage orchestrates renal maladaptive repair, contributing to the AKI to CKD transition. Blockade of NF-κB-HIF-1 signaling-mediated macrophage metabolic reprogramming may provide attractive strategy for pharmacologic therapy of the AKI to CKD transition.