Dissolvable microneedles loaded with denosumab alleviate knee osteoarthritis in rodent and canine models by inhibiting macrophage senescence

作者：Chaochang Ming, Duohang Bi, Hongtao Tian, Weijian Liu, Haitao Li, Yuxiang Hu, Zhenyu Song, Dongdong Xu, Hao Xu, Hongyan Li, Shenghui Lan, Weihua Xu, Wei Chen, Qiong Li, Jiawei Feng, Qianqian Cao, Xiaoyang Wang, Panlong Fan, Jintao Zhu, Yu Wei, Chaoge Ming, Zhipeng Dai, Yijing Liu, Wei Tong · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.116970 · 被引用次数：5 · 研究领域：Advancements in Transdermal Drug Delivery、Osteoarthritis Treatment and Mechanisms、Dermatology and Skin Diseases

Targeting senescent macrophages via MNs@De attenuates OA progression without requiring intra-articular injections or increasing systemic drug exposure. Microneedle-mediated denosumab delivery offers a minimally invasive, localized therapeutic strategy for OA.